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25 Feb 08
Lymphedema: Causes - MayoClinic.com
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Milroy disease (congenital lymphedema). This is an inherited disorder that begins in infancy and causes a malformation of your lymph nodes, leading to lymphedema.
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Meige disease (lymphedema praecox). This hereditary disorder causes lymphedema in childhood or around puberty. It causes your lymph vessels to form without the valves that keep lymph fluid from flowing backwards, making it difficult for your body to properly drain the lymph fluid from your limbs.
Transcript levels of the intermediate size or grey zone fragile X mental retardation 1 alleles are raised, and correlate with the number of CGG repeats -- Loesch et al. 44 (3): 200 -- Journal of Medical Genetics
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Such an assumption is supported by a significant association recently reported, in population-based studies, between POF and grey zone alleles.14,15 Taken together with the present results, it seems that screening studies of both POF and late-onset neurodegenerative conditions with tremor/ataxia should consider the intermediate, as well as premutation, FMR1 allele sizes.
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