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Oocyte-specific gene mutations cause premature ovarian failure

“We hope to use the information from this study and others that identify genes associated with this problem to find biomarkers in blood that can help us determine a woman’s risk of early infertility,” said Dr. Aleksandar Rajkovic, associate professor of obstetrics and gynecology at BCM and senior author of the paper. Premature ovarian failure, which means that the ovaries lose function before age 40, not only causes infertility but also bone and heart problems, he said. “It affects 1 percent of women,” he said. “While most people associate it with infertility, women with premature ovarian failure face an increased risk of cardiovascular disease, osteoporosis and premature death. Ovarian reserves are important for women’s health.” In looking for genes that cause the disorder, Rajkovic and his colleagues here and in China concentrated on those that are most likely to function in the ovary. A gene mutation does not totally halt gene activity, but Rajkovic believes it can accelerate the loss of eggs (or germ cells). When all the eggs are lost, the ovaries stop producing estrogen, leading to menopause symptoms. In this study, Rajkovic and his collaborators screened 100 Chinese women with premature ovarian failure for mutations in FIGLA and found three different kinds of mutations in the FIGLA genes of four.

Tags: oocytespecific, infertility, ovarian on 2008-05-27 -All Annotations (0) -About

more fromwww.innovations-report.de

Coping with infertility

A study published in the Malta Medical Journal shows that the unregulated and completely privatised administration of infertility treatment has led to an increase in the birth of triplets and quadruplets, a greater health risk to newborns. The article, “Higher order multiple pregnancy outcomes in the Maltese islands 2000-2004”, published last March, is a wake-up call for action in a field which successive governments have left unregulated. Reproductive technology, which includes the use of fertility pills and in vitro fertilisation, only accounts for 0.7% of single births. But the same methods were used in 28% of cases involving triplets and 50% of cases involving quadruplets. The birth of triplets and quadruplets is considered by the medical profession as more prone to health risks due to the greater likelihood that these children will be born prematurely. Charles Savona Ventura an associate Professor of Obstetrics and Gynaecology in the Faculty of Medicine and Surgery and one of the authors of the study believes that the state should start offering infertility treatments in the national health scheme. One reason for state intervention in this sector is affordability. “The problem I see is that hi-tech management of infertility in Malta is only available to those who can pay or are ready to make tremendous sacrifices to pay the costs of treatment.” Savona Ventura is concerned by the psychological impact on these parents. “Infertile couples are so desperate that they are ready to undertake extreme sacrifices to try and achieve a pregnancy. This can result in further stresses in their relationships.” One justification for a national programme to assist infertile couples is to “enable the low-moderate income groups to avail themselves of hi-tech options when necessary.” Surely prices are high because both medicines and equipment are expensive.

Tags: infertility, coping, high risks, pregnancy on 2008-05-27 -All Annotations (0) -About

more fromwww.maltatoday.com.mt

More Women Want Information About Infertility

While it may be news to some, it's not surprising that a new study touts women are seeking more information about infertility. With one in eight couples struggle at some point with their family building efforts, the information currently available is lacking. Conceive Magazine along with Fertility LifeLines, supported by EMD Serono, Inc., offer an new booklet to help women and couples in their infertility journey. The booklet is called In The Know guide and Fertility LifeLines(TM) and is available at Fertility Life Lines, but you have to register to receive the booklet. To no surprise to me, the survey found that women gather the majority of their information about infertility online and via blogs. About half of the women thought the information on infertility was sufficient. That means that about 50% of the women/couples struggling with infertility have difficultly finding the information they need to make decisions, to cope, or for support.

Tags: infertile women, infertility, family, couples on 2008-05-10 -All Annotations (0) -About

more fromwww.commonvoice.com

SUSAN SARANDON - SARANDON UNFAZED BY INFERTILITY

Veteran actress SUSAN SARANDON was unfazed when doctors told her she was infertile - because she never felt she needed a baby to make her happy. The Oscar winner admits she never longed to have kids of her own and was not especially upset when she found out she may never conceive. Sarandon resigned herself to a life without children, but, when she least expected it, she suddenly found herself pregnant.

Tags: sarandon, infertility, baby, concieve on 2008-05-10 -All Annotations (0) -About

more fromwww.contactmusic.com

Fertility and Diet

I found a fantastic article about how diet affects infertility. The article mainly addresses ovulatory infertility and there was no study on male factor infertility, although some of the same dietary concepts might apply to men too. To recap (with my commentary), the article states that there is a difference between fast and slow carbs. If you’re like me, then giving up potatoes might be an inconvenience, but if it means you can improve your ovulatory infertility than DO IT. The article continues to discuss animal versus plant protein. With ovulatory infertility, the study suggests that protein derived from plant is more helpful to ovulation than is animal protein. The higher the animal protein the more likelihood of infertility issues. The higher the animal protein the less occurrence of ovulation issues. So while you’re trying to become pregnant, eat less meat and more vegetables high in protein. My favorite part of the article deals with dairy (one of my favorite foods)…the article suggests having one full-fat dairy food serving per day. They state that a pint should last about two weeks with two half-cup servings per week. Just yesterday I was feeling guilty that I take my twin girls to Baskin Robins every Tuesday for Two-for-Tuesdays. Little did I know that I was helping their ovulatory fertility by doing so - do you think it works on 3 1/2 year olds? Somehow I doubt it. The article wraps up with the role of body weight, BMI and exercise. Weight is a determining factor in so many diseases and I wasn’t surprised to see it mentioned here. I know skinny and heavy people who had no problems getting pregnant while the perfectly fit (as this article describes) unable to conceive. So, I agree that it plays a part, but its one of the many, many pieces of fertility issues. Seems that regular exercise actually improves more than just your overall health, it helps with ovulatory fertility too.

Tags: fertility, infertility, ovulation, ovarian on 2008-04-29 -All Annotations (0) -About

more fromwww.commonvoice.com

The Right Protein Can Help With Infertility

Millions of women struggle with infertility and many of them turn to medications or medical procedures for help. In our Healthy Living report, why new research shows many of these women could improve their odds of getting pregnant simply by changing what they eat. A comprehensive study of thousands of women shows those who derive the majority of protein in their diet from animal sources can have trouble conceiving. “The more animal protein you take in the more problems you seem to have with ovulatory dysfunction,” said Dr. Keith Blauer. And swapping out animal proteins for vegetable proteins such as beans, tofu and nuts can improve the odds. “By changing the protein to vegetable protein you can improve ovulatory function,” said Dr. Blauer. Protein was just one recommendation from this study.

Tags: fertility diet, infertility, fertility on 2008-04-29 -All Annotations (0) -About

more fromwww.kutv.com

For one kind of infertility, medicines replace surgery

DEAR DR. DONOHUE: I am writing in regard to the letter from the woman diagnosed with polycystic ovary syndrome. I was diagnosed with Stein-Leventhal syndrome after many futile fertility treatments. My doctor performed an ovarian wedge surgery, and six months later I was pregnant. I conceived a second child 21 months after that. I think polycystic ovary syndrome and Stein-Leventhal syndrome are the same. Why don't I ever read about the ovarian wedge surgery for infertile women with polycystic ovary syndrome? — L.F. Doctors Stein and Leventhal first described polycystic ovarian syndrome in 1937, and the name became Stein-Leventhal syndrome. Now it's most often called polycystic ovary syndrome. Those two doctors pointed out the salient features of the syndrome: enlarged ovaries studded with cysts, loss of menstrual periods, and obesity. Infertility was another common feature. Doctors Stein and Leventhal also championed the surgical treatment of this syndrome — removal of a wedge of the ovary. The operation worked for some reason, but that reason wasn't appreciated until more recently. Removing the wedge decreased the production of male hormone, which is the basis of the syndrome. Now that new information has shown that an overproduction of male hormone is the important cause of the syndrome, there are many medicines that can be used to treat it. The wedge removal isn't necessary. For one thing, it almost always caused only a transitory drop in male hormone production. For another, it was often associated with the formation of adhesions. Taking medicines is much easier than having surgery and is a more reliable way to treat this illness, which now is known to have many features that were unrecognized in bygone years. One of those features is insensitivity to the action of insulin.

Tags: polycystic ovarian syndrome, infertility, fertility, ovarian on 2008-04-27 -All Annotations (0) -About

more fromwww.southcoasttoday.com

Infertility - Causes, Symptoms, Treatment, Diagnosis

The Facts Infertility is usually defined as the inability to become pregnant after one year of sex without birth control. It affects about 10% of couples of reproductive age. In about one-third of cases, it's attributed to the man, and a similar proportion is due to problems in the woman. In the other third of cases, either both partners have problems, or the cause of the infertility is never found. There is often overlap of the causes with combined factors in up to 20% of couples. People shouldn't assume that they or their partners are infertile until they've tried and failed to conceive for at least six months if the female partner is 35 years or older or for at least one year if the female partner is less than 35 years. If you still are not able to get pregnant after this time, check with your doctor. Fortunately, it's not uncommon for couples to suddenly conceive a child without treatment after years of trying unsuccessfully. Causes There are hundreds of medical problems that can cause infertility in both men and women. Causes of infertility in men include: * hormone disturbance * smoking * overheating of the testicles caused by exercise, hot water, tight clothing, excessive sitting (truck drivers) and other conditions and situations * cancer drugs and radiation therapy * mumps after puberty * sexually transmitted diseases * anatomical abnormalities of the genitals such as undescended testicles * use of some medications, such as some antihypertensives, some antidepressants, and male hormones * genital injury * prostate surgery * varicose veins in the testicles * excessive alcohol * intercourse problems such as premature withdrawal or poor timing with their partner's menstrual cycle * spinal cord injury * genetic abnormalities * urinary tract infection * cystic fibrosis

Tags: infertility treatment, causes of infertility, fertility problems, infertility on 2008-04-25 -All Annotations (0) -About

more fromhealth.myfoxtoledo.com

A new form of cheaper, more natural IVF that could beat infertility and make you a mum

After years of using more and more drugs to boost fertility, doctors have found a new way to help women have babies... by going back to basics By Adele Waters 22/04/2008 IVF mums Marina (L) and Siobhan IVF mums Marina (L) and Siobhan Related Articles * Twin to Twin Transfusion Syndrome: I carried my dead baby to save his twin * Dear Miriam - A problem shared: Lost without a dad * More Your Life * What are you talking about? Get published * Showbiz pictures Related Tags * dr geeta nargund, * fertility, * infertility, * ivf, * marina murphy, * mild ivf, * ovaries, * pregnancy, * professor bart fauser, * siobhan mclernon, * soft ivf (What's this?) Every year, thousands of women suffer terrible physical side-effects and heartbreak as they go through gruelling IVF in their desperation to become mums. But now, a revolutionary new form of IVF could make their dreams come true without the suffering and at a fraction of the cost. The technique - Soft IVF - uses fewer drugs, significantly reducing the side-effects which the hormone injections in conventional treatment often cause. It is also around half the price of the standard approach - about £2,000 compared to at least £4,000. Advertisement This month, at a fertility conference in London, doctors agreed Soft IVF was the future in fertility medicine. They said the treatment - also known as Mild IVF - has good success rates and is safer for women because it interferes less with their body's natural chemistry.

Tags: infertility treatment, ivf, infertility on 2008-04-24 -All Annotations (0) -About

more fromwww.mirror.co.uk

Research Financing For Contraception and Infertility Investigations

Those Planning to research on contraception or infertility or those who want to pursue their studies and are willing to dedicate the last years of their studies and the first years of their careers to researching on such topics, will find that there are grants available for repaying their student debt. These repayment programs are awarded to health professionals or students who need to repay their student debt. These Programs repay the educational loans that the applicants took to pursue their college studies in exchange for committing to investigate on the fields of contraception and infertility. It is an excellent opportunity for those who are interested on the fields or for those who are worried about the repayment of their student debt and do not mind or find interesting the subjects of contraception and infertility. Objectives of The Program The extended objective of the contraception and infertility research loan repayment program is to achieve an increase on the interest of professionals on the fields of the program and to make them focus their careers on these fields to obtain expert professionals that can fulfill the needs of the community on contraception and infertility.

Tags: infertility, contraception, financing on 2008-04-16 -All Annotations (0) -About

more fromwww.losangeleschronicle.com

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Finding cause of infertility requires thorough testing

Infertility is defined as a full year of trying to become pregnant without any success. Infertility involves many factors: hormones, egg production and egg release, normal fallopian tubes (the tubes through which an egg migrates to the uterus) and a normal uterus. Men are solely responsible for 20 percent of infertility, and they contribute to it 30 percent to 40 percent of the time. A basic test for the determination of male fertility is a sperm count, something the doctor can arrange for your husband. In considering female problems, the doctor has to evaluate a woman's menstrual history, her hormone status and her monthly release of an egg. The woman's uterus and fallopian tubes have to be examined to determine if there is some anatomy problem that makes conception difficult. Blocked fallopian tubes, for example, prevent pregnancy. A common cause of infertility is polycystic ovary syndrome. Women with this syndrome make too much male hormone, have large ovaries studded with cysts and are often overweight. Sometimes simple weight loss can correct many of the problems that arise from this syndrome, including difficulty in becoming pregnant. Perhaps that's what the doctor meant by weight loss. I don't know how drinking water corrects anything. My message to you is that finding the answer to infertility requires much testing and includes the husband in the testing process. There's no simple solution to this difficult situation.

Tags: egg production, infertility, hormones, pregnant on 2008-04-16 and saved by2 people -All Annotations (0) -About

more fromwww.southcoasttoday.com

Fertility accupuncture

About ten percent of women in the United States face some difficulty getting pregnant. Fortunately there are many options available to help overcome infertility, including acupuncture. Michele Sweeney is enjoying the best job she said she's ever had, being mom to three-month-old Brodie. Because she is in her early 40s, doctors advised Sweeney try in-vitro fertilization right away. She did twice and it did not work. "It's the emotional part that's the hard part. It's very hard when you see friends around you getting pregnant without any assistance and you're spending all kinds of money and time and it's a huge commitment, and at the end of all that you don't have a pregnancy," she said.

Tags: accupuncture, infertility, fertility on 2008-04-08 -All Annotations (0) -About

more fromwww.wcbd.com

The Burden of Infertility Financials

Infertility financial help is worth a look for couples who are facing infertility. Infertility treatments are costly and if you intended to go for the full course, there is a need to consider financial aid to fund the infertility treatments. You may be able to afford the cost of treatments or you might need financial assistance.

Tags: Infertility, Natural, Treatments, For, infertility on 2008-04-07 -All Annotations (0) -About

more fromwww.fightinginfertility.com

Fertility treatments and the cost to conceive

According to the Center for Disease Control's (CDC) 2002 National Survey on Family Growth, 1.2 million of the estimated 62 million women in their reproductive years – that's two percent – have had infertility-related medical appointments; 10% have received infertility services. The American Society of Reproductive Medicine (ASRM) reports that most infertility cases – 85%-90%, in fact – are treated with conventional medical therapies (medication or surgery.) But for some, in vitro fertilization and other Assisted Reproductive Technologies (ART) are needed to try and conceive. Intrauterine insemination (IUI) How does it work: Intrauterine insemination, also known as artificial insemination, involves a woman being injected with washed and treated sperm from her husband or a donor during ovulation. During this time, she must also take fertility drugs to stimulate egg production. Couples may try IUI if there is a problem with low sperm count or mobility, or another unexplained infertility condition. How much does it cost? Costs associated with IUI's vary, as with other procedures, and are dependent on how many cycles a woman goes through and whether the sperm is donated, as well as additional costs associated with medication, ultrasounds and monitoring. Ranges for IUI cycles can be anywhere from the mid $300's to the $1000's, and, as with all infertility treatments, eligibility for insurance coverage depends on where you live, the clinic you are visiting and your insurance carrier.

Tags: donor egg, IUI, IVF, infertility, fertility, sperm on 2008-04-05 -All Annotations (0) -About

more fromwww.sheknows.com

In Recognition Of 30 Years Of IVF

This year's National Infertility Day (NID) conference recognises 30 years of IVF by welcoming as our opening speaker Professor Robert Edwards, who alongside his late colleague Sir Patrick Steptoe was one of the pioneers of IVF. In addition we are delighted to also welcome Professor Andre Van Steirteghem, the pioneer of intra-cytoplasmic sperm injection (ICSI) which gave the chance of a child to those affected by male infertility. The conference will take place on 19th July 2008 at The New Connaught Rooms in central London. We have the most distinguished list of more than 30 other speakers delivering talks on subjects ranging from medical areas such as donor issues, male and female infertility and new developments including in vitro maturation and the issue of single embryo transfer. We will also cover related topics including nutrition, Chinese medicine, adoption, surrogacy and much more. There will also be a session looking at what to do if treatment fails.

Tags: chinese medicine, ivf, infertility, fertility, invitro on 2008-04-05 -All Annotations (0) -About

more fromwww.medicalnewstoday.com

Study raises questions about cell phones and infertility | APP.com | Asbury Park Press

Are men speed-dialing infertility by talking for hours a day on their cell phones? A new study suggests that might be the case, but before potential papas ditch the devices, they should know that lead author Ashok Agarwal says the data are "quite preliminary." Cell phones emit radiofrequency electromagnetic waves. Scientists have reported potential adverse effects of the waves on the brain, heart, endocrine system and DNA, Agarwal, director of the andrology lab at the Cleveland Clinic Foundation, and his co-authors write in the journal Fertility and Sterility.

Tags: app.com, fertility, infertility, sterility on 2008-04-02 -All Annotations (0) -About

more fromwww.app.com

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Acupuncture May Solve Fertility Problems

After a failed attempt at in vitro fertilization, an unsuccessful frozen embryo transfer and other fertility treatments, Caren Harvey and her husband, Paul, were emotionally, physically and financially exhausted. Three years earlier, fertility treatments and surgery had made the couple's dream of having a baby a reality. Perhaps, they decided, a second child was not to be. "We were devastated," says Harvey, 38, of her last unsuccessful attempt at a frozen embryo transfer. "Do we give up? What do we do? Do we just embrace our one baby and be happy, or do we try for another child and continue to torture ourselves?" The Harveys decided to try once more. But this time, they used an ancient Chinese medical procedure as part of their treatment. They credit the birth of their second daughter, Brooke Judith, born in January 2007, to acupuncture — at least in part. "We thought it was a little quirky at first," recalls Harvey. "I'm a nurse, so this felt very odd to me. Western medicine is very traditional; then you walk into an office, and this beautiful soft music is playing and she's looking at my tongue and telling me what [my body] is lacking. I know it [acupuncture] made a dramatic change. I really wish I had done this before I tried anything else."

Tags: acupuncture, fertility, infertility, treatments on 2008-03-29 -All Annotations (0) -About

more fromwww2.tbo.com

First Sex Chromosome Gene Involved In Meiosis And Male Infertility Identified

A team of scientists led by University of Pennsylvania veterinary researchers have identified a gene, TEX11, located on the X chromosome, which when disrupted in mice renders the males sterile and reduces female fecundity. This is the first study of the genetic causes of infertility that links a particular sex chromosome meiosis-specific gene to sterility.

Tags: infertility, meiosis, research on 2008-03-29 -All Annotations (0) -About

more fromwww.sciencedaily.com

Free Workshop For Infertility

Free Workshop For Infertility Winthrop-University Hospital will offer a free workshop, "When Hope is Not Enough," for women and their partners who are frustrated in their efforts to have a baby. The program will be held on Monday, April 7, 2008, at 6:30 PM at Winthrop's Community Outreach Center, located at 101 Mineola Boulevard in Mineola. Couples can learn how they can optimize their chances of conceiving a child from Linda Sung, MD, a specialist in Reproductive Endocrinology and In-fertility. Dr. Sung will discuss how infertility is defined, what couples can do about it, and the latest information on treatment options. "There are many treatments available for fertility, but it's important to individualize the treatment according to the needs of couple," she said. A question and answer period will be included in the lecture. Parking and the entrance are in the rear of the building. Admission is free, but seating is limited; refreshments will be served. Reservations are required. To reserve your seat, please call 1-866-WINTHROP. Winthrop is a member of Spirt of Women(r), a coalition of American hospitals and healthcare providers that ascribe to high standards of excellence in women's health, education and community outreach.

Tags: clinic, fertility, infertility on 2008-03-29 -All Annotations (0) -About

more fromwww.gcnews.com

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