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08 Nov 09

ScienceDirect - Biological Psychiatry : The Role of COMT Val158Met in Cognition

  • Does the meta-analysis of Barnett et al. (1), “Meta-Analysis of the Cognitive Effects of the Catechol-O-Methyltransferase Gene Val158/108Met Polymorphism,” justify their conclusion that “Despite initial promising results, the COMT Val158/108Met polymorphism appears to have little if any association with cognitive function”? We submit that this statement illustrates the potential shortcomings of a purely statistical evaluation of a domain of inquiry that has penetrated to the deeper level of biological mechanisms
27 Oct 09

The Atlantic article: sur rebuttal : Effect Measure

  • they apparently can't separate their role as journalists from the role of Dr. Jefferson as the person we accused of methodolatry
  • It attempted to persuade people there is a real question about the usefulness of influenza vaccine during a pandemic, a time when the public is trying to understand what to do. It confused pretty much everyone who read it on that scor
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Knight Science Journalism Tracker » Blog Archive » The Atlantic on flu vaccines: Responses.

  • We’re simply saying that the nation’s seasonal flu strategy, which is to vaccinate the elderly and other vulnerable populations, may not be working as well as has been claimed.  If we rely on vaccine during a major, deadly pandemic (which thus far this one does not appear to be, but things could change), the public may not be as well protected as we might hope or believe. We don’t say flu vaccine is worthless, we simply say nobody really knows how much protection it might offer.  Better studies would help define what vaccine can and can’t do – and help us prepare for the really nasty pandemic that many experts believe is only a matter of time.
22 Oct 09

Viewing Feed

  • Almost 15% of adults under 65 lack insurance, and many, many more are uninsured
  • We may be rising in the national rankings. But we’re worse off now than we were 5 years ago.
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Goodbye HuffPost, Hello ScienceBlogs: Science as a Religion that Worships Truth as its God : Evolution for Everyone

  • The second major issue that requires scientific reform is group selection, a theory that explains how groups can become well adapted to their environments in the same sense that individuals do. The theory of group selection began with Darwin and involves a simple set of issues that anyone can understand. Yet, it remains endlessly controversial. Next year marks the 35th anniversary of my first publication on group selection and I'm confident that the controversy will continue for decades more unless something is done. That "something" is a truth and reconciliation process, similar to the resolution of political conflicts that otherwise might continue forever. The idea that a scientific controversy might require a truth and reconciliation process similar to a political controversy speaks volumes about science as a fallible and culturally influenced process.



    My

20 Oct 09

Technology Review: Flu Vaccines Hit a Wall

  • Perhaps the most exciting but challenging prospect for a universal vaccine lies in DNA-based vaccines--sequences of DNA that, when taken up by cells and expressed as proteins, prompt an immune response. DNA vaccines can be made and modified quickly, are cheap to produce, and have a long shelf life
17 Oct 09

This Is Your Wake-up Call: 12 Steps to Better Book Publishing - 4/20/2009 - Publishers Weekly

  • Greg Mortenson and David Oliver Relin's Three Cups of Tea, for example, has been sustained by a dynamic author and a multi-year speaking tour, and the hit Twilight series has greatly benefited from Stephenie Meyer's extensive online promotional efforts
10 Oct 09

Paying More, Getting Less | Dollars & Sense

  • For insurance premiums: in 2007, the average annual premiums for health insurance policies offered through employers were $4,479 for individuals and $12,106 for families, according to the Kaiser Family Foundation’s annual survey of health benefits.
  • Either way, however, the full premium cost represents a bite taken out of the worker’s total “wage packet”—the cost of wages plus benefits

Migration of Doctors and Nurses from Developing to Developed Countries - May 09, 2008 -May 9, 2008 - Harvard Public Health NOW - Harvard School of Public Health

  • Migration of Doctors and Nurses from Developing to Developed Countries






























    Is the "brain drain" of doctors and nurses from poor to rich countries hurting health care in those developing lands? Is the massive inflow of donor dollars to pay for HIV/AIDS treatment in poor countries diverting resources away from other health concerns in those already underserved places?

  • Kicking off the symposium, Lincoln Chen, president of the China Medical Board and founder of the Global Equity Initiative at Harvard University's Asia Center, cautioned the audience about simplistic conclusions based on incomplete data and insufficient analyses. Statistics do not tell the whole story, he argued, noting that the migration of doctors can be a serious problem.
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An Iron Fist Joins the Malaria Wars - New York Times

  • He's a breath of fresh air," said Amir Attaran, a biologist and lawyer at the University of Ottawa who has accused the W.H.O., the World Bank and the Global Fund to Fight Aids, TB and Malaria of squandering millions on old, useless drugs.

    "You need to talk tough," he added. "There has been absolute incoherence on fundamental issues."

  • Dr. Attaran, a longtime W.H.O. critic, also praised Dr. Kochi for being one of the first at the agency to realize that AIDS could be treated in Africa with standard regimens of cheap drugs and simple blood tests, instead of Western-level care costing tens of thousands of dollars a year.

    In the 90 days before his deadline expired, Dr. Kochi met with generic drug-makers, many of whom are trying to shift from duplicating Western drugs to researching new ones. He told them, he said, that they would face a public relations fiasco if they made malaria worse.

    Caroline Jansen, a member of the family that owns Dafra Pharma, a Belgian company that supplies about 25 percent of Africa's private market for malaria drugs, said her company had agreed to stop selling monotherapy and was developing pills mixing artemisinin with lumefantrine, amodiaquine and other drugs.

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An Iron Fist Joins the Malaria Wars - New York Times

  • The war on malaria — in theory more winnable than the war on AIDS because a cure exists — is instead being lost, Dr. Kochi says. In the 1960's, malaria was considered potentially eradicable: DDT and chloroquine, a synthetic form of quinine, had been invented, and much of the tropics were under colonial rulers who, whatever their other faults, were good at killing mosquitoes.

    Since then, DDT has been withdrawn because of its environmental damage, chloroquine and its successor, Fansidar, have become all but useless and the health systems in most of Africa and parts of Asia and Latin America have collapsed.

  • The body count is now at least one million a year, most of them children and pregnant women. There are 350 million cases of malaria each year; people may catch it repeatedly in hot seasons and be too weak to work, so it cripples rural economies
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Gates Keepers :: The Gates Foundation and Ann Arbor

  • The Gates Foundation is based in Seattle and has offices in Washington, D.C. and India, according to its Web site. It employs about 520 and has an endowment totaling $38.7 billion. It paid out $2 billion in grants last year and has paid out a total of $16.3 billion across mainly its three grantmaking areas, including global health, since its inception.
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