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18 May 08

Slashdot | Using Magnets To Turn Off the Brain's Speech Center

  • You're making the classic engineering mistake: mis-defining the problem.

    Disrupting the speech centers of the brain does not preempt attempts at communications. And you need communication; it's just that men, left to themselves, would communicate by passing terse status messages: "I'm hungry"; "I'm angry"; "I'm going to sleep"; "I want sex."

    Women send the same status messages, but they seem to gain satisfaction out of the process itself. Therefore they send messages in steganographic form: the basis status messages are there, wrapped all kinds of other data which do not require your immediate action. It pays to pay at least some attention; she may start an "I want sex" status message by telling you that her sister's neighbor's aunt is going in for a gall stone operation.

    The wise man knows that he should celebrate the differences between the sexes if he wants to celebrate the difference between the sexes.

    Therefore, it is best to cultivate the skill of appearing mildly interested and engaged, making reflexive, non-committal listening responses, and paying just enough attention to pick out any cues that indicate something that requires immediate action. It's a lot like driving, actually. You get that sixth sense for when somebody is going to cut you off, or roll into an intersection without coming to a stop. It's not magic, it's practice.

BioMed Central | Abstract | 1471-2202-9-22 | Peripheral injection of human umbilical cord blood stimulates neurogenesis in the aged rat brain

  • is continues to occur throughout life but dramatically decreases with increasing age. This decrease is mostly related to a decline in proliferative activity as a result of an impoverishment of the microenvironment of the aged brain, including a reduction in trophic factors and increased inflammation.


    Results


    We determined that human umbilical cord blood mononuclear cells (UCBMC) given peripherally, by an intravenous injection, could rejuvenate the proliferative activity of the aged neural stem/progenitor cells. This increase in proliferation lasted for at least 15 days after the delivery of the UCBMC. Along with the increase in proliferation following UCBMC treatment, an increase in neurogenesis was also found in the aged animals. The increase in neurogenesis as a result of UCBMC treatment seemed to be due to a decrease in inflammation, as a decrease in the number of activated microglia was found and this decrease correlated with the increase in neurogenesis.


    Conclusion


    The results demonstrate that a single intravenous injection of UCBMC in aged rats can significantly improve the microenvironment of the aged hippocampus and rejuvenate the aged neural stem/progenitor cells. Our results raise the possibility of a peripherally administered cell therapy as an effective approach to improve the microenvironment of the aged brain

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