Home
AMP-Activated Protein Kinase, AMPK
"AMP-activated protein kinase (AMPK) was first discovered as an activity that inhibited preparations of acetyl-CoA carboxylase (ACC) and 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase, HMGR) and was induced by AMP. AMPK induces a cascade of events within cells in response to the ever changing energy charge of the cell. The role of AMPK in regulating cellular energy charge places this enzyme at a central control point in maintaining energy homeostasis. More recent evidence has shown that AMPK activity can also be regulated by physiological stimuli, independent of the energy charge of the cell, including hormones and nutrients.
Once activated, AMPK-mediated phosphorylation events switch cells from active ATP consumption (e.g. fatty acid and cholesterol biosynthesis) to active ATP production (e.g. fatty acid and glucose oxidation). These events are rapidly initiated and are referred to as short-term regulatory processes. The activation of AMPK also exerts long-term effects at the level of both gene expression and protein synthesis. Other important activities attributable to AMPK are regulation of insulin synthesis and secretion in pancreatic islet β-cells and modulation of hypothalamic functions involved in the regulation of satiety. How these latter two functions impact obesity and diabetes will be discussed below. "
Wikipedia:WikiProject Molecular and Cellular Biology - Wikipedia, the free encyclopedia
"This project aims to better organize information in articles related to molecular and cell biology on Wikipedia. A major problem facing biology is organizing the vast amount of information that has been and continues to be collected about genomes, proteomes and cell function. A primary goal of this project is to collect and organize the totality of this information and make it accessible to researchers and laypeople alike by providing an entry point to the wealth of biological data that is currently hidden in obscure databases and journal articles.
If you would like to help, feel free to add yourself to the list of participants, or just look over the How you can help section below. Also of interest is the Molecular and Cellular Biology Portal associated with this project."
AMP-activated protein kinase - Wikipedia, the free encyclopedia
"5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme, conserved from yeast to humans. It is expressed in a number of tissues, including the liver, brain, and skeletal muscle. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation and ketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake, and modulation of insulin secretion by pancreatic beta-cells.[1]
It should not be confused with cyclic AMP-activated protein kinase (protein kinase A), which, although being of similar nature, may have opposite effects.[2]"
Terveeksi ravinnolla: D-vitamiini saattaa hillitä eturauhassyöpää
"Riittävä D-vitamiinin saanti saattaa parantaa eturauhassyöpää sairastavien ennustetta. Tähän viittaa tuore norjalaistutkimus, johon osallistui 160 eturauhassyöpää sairastavaa miestä. Tulokset julkaistiin British Journal of Cancer -lehdessä.
Tulosten perusteella runsaasti tai kohtalaisesti D-vitamiinia saavat kuolivat noin nelivuotisen seurannan aikana selvästi epätodennäköisemmin kuin potilaat, joiden veressä oli vähänlaisesti D-vitamiinia. Vitamiinipitoisuudet oli mitattu ennen tutkimuksen alkamista.
D-vitamiiniin liitetty vaikutus oli suurin potilailla, jotka olivat saaneet hormonihoitoja ennen verinäytteiden ottamista"
Suomeen on tulossa luontaissairaala - Uutisarkisto - Mediuutiset
"Suomeen on perustettu ensimmäinen koululääketieteen ja luontaishoidot yhdistävä hoitalaitos. Toiminnan käynnistänyt osuuskunta kutsuu toimintaansa luontaissairaalaksi. Toiminnan tavoite on saada ihminen viikon kestävällä puhdistuskuurilla uuden elämän alkuun. Asiasta kertoo maanantain Turun Sanomat.
Osuuskunta järjesti ensimmäisen viikon mittaisen intensiiviopastuksen Iittalassa. Vakituiset toimitilat luontaissairaalalta vielä puuttuvat, mutta ne halutaan käyttöön helmi-maaliskuussa.
- Neuvottelemme parhaillaan kolmesta eri kiinteistöstä, kertoo osuuskuntaa johtava yleislääketieteen erikoislääkäri Sauli Siekkinen lehdessä. "
Mozambican Grass Seed Consumption During the Middle Stone Age -- Mercader 326 (5960): 1680 -- Science
Mozambican Grass Seed Consumption During the Middle Stone Age
Julio Mercader
Science 18 December 2009:
Vol. 326. no. 5960, pp. 1680 - 1683
DOI: 10.1126/science.1173966
The role of starchy plants in early hominin diets and when the culinary processing of starches began have been difficult to track archaeologically. Seed collecting is conventionally perceived to have been an irrelevant activity among the Pleistocene foragers of southern Africa, on the grounds of both technological difficulty in the processing of grains and the belief that roots, fruits, and nuts, not cereals, were the basis for subsistence for the past 100,000 years and further back in time. A large assemblage of starch granules has been retrieved from the surfaces of Middle Stone Age stone tools from Mozambique, showing that early Homo sapiens relied on grass seeds starting at least 105,000 years ago, including those of sorghum grasses.
Observations: Humans feasting on grains for at least 100,000 years
"Grains might have been an important part of human diets much further back in our history than previous research has suggested.
Although cupcakes and crumpets were still a long way off during the Middle Stone Age, new evidence suggests that at least some humans of that time period were eating starchy, cereal-based snacks as early as 105,000 years ago. The findings, gleaned from grass seed residue found on ancient African stone tools, are detailed online Thursday in Science.
Researchers have assumed that humans were foraging for fruits, nuts and roots long before 100,000 years ago, but cereal grains are quite a new addition to the early prehistoric gastronomic picture. "This broadens the timeline for the use of grass seeds by our species," Julio Mercader, an assistant professor at University of Calgary's Department of Archeology and author of the paper, said in a prepared statement. "
LDL-kolesterolin reseptori vaikuttaa Alzheimerin taudin plakkien kertymään | Ohjelmaopas | yle.fi
"Huonomaineinen LDL-kolesteroli saattaa olla eduksi dementiaa aiheuttavan Alzheimerin taudin estämisessä, havaittiin Yhdysvalloissa tehdyssä tutkimuksessa. Hiirillä tehdyssä kokeessa LDL-kolesterolin tietyn reseptorin, LDLR:n määrän lisääminen aivoissa pienensi Alzheimerin taudille tyypillisten amyloidiplakkien kertymistä aivoihin ja niiden aiheuttamia hermovaurioita. Havainto mahdollistaa uudenlaisten dementialääkkeiden kehittämisen."
Durrat – Wikipedia
"Durrat (Sorghum) on kasvisuku, joka käsittää noin 60 lajia. Durraa käytetään ihmisten ja kotieläinten ravinnoksi Afrikassa, Intiassa ja Etelä-Amerikassa. Alkujaan durra on kotoisin Afrikasta, missä sen käyttö on edelleen yleisintä. Durra on vehnän, kauran, maissin ja ohran ohella yksi maailman viidestä käytetyimmästä viljasta."
Durran jyviä syötiin jo 100 000 vuotta sitten, väittävät kanadalaistutkijat | Ohjelmaopas | yle.fi
"Mosambikissa eteläisessä Afrikassa eläneet ihmiset ovat syöneet viljakasvi durran jyviä jo 105 000 vuotta sitten, päättelee kanadalainen tutkijaryhmä. Jos päätelmä pitää paikkansa, se aikaistaa ihmislajin viljan jyvien syömistä 80 000 vuodella. Johtopäätös perustuu syvästä luolasta löytyneissä kiviesineissä olleiden tärkkelysjyvästen analyysiin.
Tätä ennen varhaisin tunnettu viljanjyvien hyödyntäminen on todistettavasti tapahtunut Välimeren itäpäässä, Israelin alueelta löydetyllä kivikautisella asuinpaikalla joka on ajoitettu 23 000 vuoden taakse. Viljansiemenien syöminen aikaistuisi löydön perusteella melkoisesti suuri eivätkä kaikki asiantuntijat ole vakuuttuneita kanadalaistutkijoiden tulkinnasta.
Nykyihmislaji on syntynyt noin 150 -200 000 vuotta sitten Afrikassa. Näiden ihmisten elämäntavat eivät poikenneet muista samaan aikaan eläneistä hominiineista. 100 000 vuotta sitten ruokavalion on oletettu koostuneen kasvi- ja eläinkunnan tuotteista kuten kasvien juurista, pähkinöistä ja hedelmistä ja satunnaisista lihanpaloista. Viljakasvien jyvät ovat pienempiä ja vaikeammin valmistettavia kuin monet muut, joten niiden hyödyntämisen on päätelty alkaneen vasta myöhemmin. Viljan viljely alkoi noin 15 000-10 000 vuotta sitten mutta ensin on syöty villien kantalajien jyviä."
NephroPal: Summer vs Winter Mode: Explaining AMPK
"Summer vs Winter Mode: Explaining AMPK
Last year I read an article which made a statement that has not left my mind. The statement went as follows: "You are only good as your mitochondria." In fact, the more a dwell into the details of human metabolism, the more I sense that this is true - especially with the metabolic syndrome.
For those who are not familiar with the concept of mitochondria, they are the tiny energy factories within the cells that produce cellular energy through aerobic means (meaning oxygen). Mitochondria utilize oxygen to ultimately produce Adenosine Triphosphate or simply ATP. ATP relays energy by donating a phosphate bond resulting in Adenosine Diphosphate (ADP). Another phosphate release would entail Adenosine Monophosphate or AMP. ATP is one of the main sources of cellular energy in the body."
NephroPal: PPARs
"Summer vs Winter Mode: Explaining AMPK
Last year I read an article which made a statement that has not left my mind. The statement went as follows: "You are only good as your mitochondria." In fact, the more a dwell into the details of human metabolism, the more I sense that this is true - especially with the metabolic syndrome.
For those who are not familiar with the concept of mitochondria, they are the tiny energy factories within the cells that produce cellular energy through aerobic means (meaning oxygen). Mitochondria utilize oxygen to ultimately produce Adenosine Triphosphate or simply ATP. ATP relays energy by donating a phosphate bond resulting in Adenosine Diphosphate (ADP). Another phosphate release would entail Adenosine Monophosphate or AMP. ATP is one of the main sources of cellular energy in the body
NephroPal: Evolutionary Lifestyle
"Should you eat low carbohydrate and high saturated fat, or high carbohydrate and low fat, that is the question? This question is causing a tremendous back and forth in the medical and nutrition industry. It is unbelievable that the medical profession has not at least thoroughly tested the question. How is it that a magnificent experiment had been going on for 2.5 million years, the hunter gatherer Paleolithic life. This continued up to and until about about 10,000 years ago, with the advent of agriculture. After that time is when the diseases of the metabolic syndrome started to appear. This information is a matter of history. If a layman like me can recognize the validity of an experiment that continued for 2,5 million years, and produced healthy individuals, relative to the diseases of the metabolic syndrome, such as: obesity, diabetes type 2, cardiovascular disease and stroke, and some cancers to name just a few, then how is it, that the consensus opinion of the medical profession and nutritionists think that the hunter gatherer lifestyle of our ancient ancestors is unhealthful or dangerous? The consensus opinion says that low fat (trim all visible fat from the animal protein) and high carbohydrate food is the "healthy eating" choice for us. I personally know that instead of being healthy,it is unhealthy, because by following my doctors advice over the last 50 years many of the above mentioned diseases started to appear on my charts. "
NephroPal: Vitamin D - The saga goes on...
"Had enough about reading/hearing about Vitamin D? Well, it keeps on coming. And for my lack of surprise, the medical community in general is not catching on like wild fire. I really don't understand it.
A recent study from the Heart Institute at Intermountain Medical Center in Salt Lake City (click) followed 27,686 patients greater than 50 years of age with no prior history of cardiovascular disease. The Vitamin D levels were checked and classified as such:
* normal - greater than 30 ng/ml
* low - 15 to 30
* very low - less than 15
The results of the study showed that patients with very low Vitamin D levels in comparison to normal had:
* 77% greater risk of death
* 45% increased risk of coronary artery disease
* 78% increased risk of stroke
* twice the risk of developing heart failure"
NephroPal: Omega 3 Fatty Acid and Adiponectin Levels
"Friday, December 18, 2009
Omega 3 Fatty Acid and Adiponectin Levels
Today my wife was watching the Oprah show. A commercial came on and I looked up. It was a Christmas special on liposuction in the local area. Considering that the fat tissue (adipose tissue) is now viewed as an endocrine organ and not just a collection of fat cells, I have always thought that sucking out the fat cells maybe a bad idea. Yet, I have never seen proof of this. But, the science of the adipose tissue as an endocrine organ is relatively new. It seems that in the medical literature adiponectin is receiving the most attention from all of the other adipose hormones - or also referred to as adipokines. This is for good reason. As stated before, adiponectin has the following effects:
* reduces liver glucose production
* increases glucose uptake in the muscles and adipose tissues
* causes oxidation of fats which leads to less lipid production
* has anti-inflammatory properties
* protects the heart against ischemia and reduces myocardial infarct size
* acts as an anti-clotting factor
* increases nitric oxide production in the vasculature leading to a greater dilation of the vessels"
Anti-ageing pill developed that 'cuts wrinkles and makes skin look younger' - Telegraph
"A one-a-day pill the size of a Smartie that claims to be able to give younger looking skin and fewer wrinkles is being hailed as the latest weapon against ageing.
Known as Innéov Fermeté, it is claimed that taking one of these pills just once a day will lead to a younger appearance by harnessing the health-giving properties of tomatoes.
Scientists who designed the pill claim that trials have shown it dramatically slows down the ageing of the skin.
Jointly developed by food giant Nestlé and L’Oréal, the world’s biggest cosmetics company, the pill uses a compound found in tomatoes to promote the regeneration of new skin cells and protect old ones from damage.
The sweet red pill has already gone on sale in parts of Europe and South America. "
5 Free PDF Converters for Windows Users – Make Tech Easier
"Wouldn’t it be great if Windows comes with its own PDF converter? Unfortuately, it does not. With PDF being one of the preferred ways of protecting and sending documentation to others, we need a way to convert any document format into PDF. In case you are searching for such tool, here are five of the best free PDF converters for Windows users:"
Top Tags
Sponsored Links
View All Recent Tags (50)
- 722009,
- 40nutrition,
- 31joulukuu,
- 30December,
- 28terveys,
- 22uutinen,
- 18ravitsemus,
- 17news,
- 13study,
- 13vitamin_D,
- 11humans,
- 11medline,
- 10research,
- 9CVD,
- 9omega-3,
- 8diet,
- 8sijoittaminen,
- 7info,
- 7D-vitamiini,
- 7blog_article,
- 7November,
- 6syöpä,
- 6clinical_trial,
- 5yle,
- 5NephroPal,
- 5CHD,
- 5risk,
- 5vitamin_D3,
- 5rct,
- 525ohd,
- 5diabetes,
- 5DHA,
- 5arvopaperi,
- 5ehkäisy,
- 5Kebnekaise,
- 4Protein,
- 4AMPK,
- 4AMP,
- 4ruokavalio,
- 4adiponectin,
- 4metabolic_syndrome,
- 4EPA,
- 4may,
- 4verkkokauppa,
- 4kauppa,
- 4manninen,
- 4comparison,
- 4supplements,
- 4vs.,
- 4versus
Public Tags (3000)
Matti Narkia's Public Lists (18)
Diigo is about better ways to research, share and collaborate on information. Learn more »
Join Diigo