Member since Oct 13, 2009, follows 0 people, 0 public groups, 7 public bookmarks (7 total).
More »
Recent Bookmarks and Annotations
-
My Library on 2009-10-16
-
<!--leftColumn-->
This is your library page, which shows items (webpages, highlights, notes, snapshots, etc) that have been saved. For now, you haven't saved anything yet.
-
-
-
Nerve - Wikipedia, the free encyclopedia on 2009-10-14
-
A nerve is an enclosed, cable-like bundle of peripheral axons (the long, slender projections of neurons). A nerve provides a common pathway for the electrochemical nerve impulses that are transmitted along each of the axons. Nerves are found only in the peripheral nervous system. In the central nervous system, the analogous structures are known as tracts.[1][2] Neurons are sometimes called nerve cells, though this term is technically inaccurate since many neurons do not form nerves, and nerves also include non-neuronal Schwann cells that coat the axons in myelin.
-

- 2 more annotations...
-
-
Endorphin - Wikipedia, the free encyclopedia on 2009-10-14
-
Endorphin

· Biology
From Wikipedia, the free encyclopedia
<!-- start content -->
"Runner's high" redirects here. For the album by the Japanese band The Pillows, see Runners High.proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin) Identifiers Symbol POMC Entrez 5443 HUGO 9201 OMIM 176830 RefSeq NM_000939 UniProt P01189 Other data Locus Chr. 2 p23 For other uses, see Endorphin (disambiguation).Endorphins are endogenous opioid polypeptide compounds. They are produced by the pituitary gland and the hypothalamus in vertebrates during strenuous exercise,[1] excitement, pain and orgasm,[2][3] and they resemble the opiates in their abilities to produce analgesia and a sense of well-being. Endorphins have also been shown to be released in profound relaxation in a float tank.[4] Endorphins work as "natural pain relievers."
The term "endorphin" implies a pharmacological activity (analogous to the activity of the corticosteroid category of biochemicals) as opposed to a specific chemical formulation. It consists of two parts: endo- and -orphin; these are short forms of the words endogenous and morphine, intended to mean "a morphine-like substance originating from within the body."[5]
The term endorphin rush has been adopted in popular speech to refer to feelings of exhilaration brought on by pain, danger, or other forms of stress,[1] supposedly due to the influence of endorphins. When a nerve impulse reaches the spinal cord, endorphins are released which prevent nerve cells from releasing more pain signals. Immediately after injury, endorphins allow humans to feel a sense of power and control over themselves that allows them to persist with activity for an extended time.
-
Mechanism of action
Beta-endorphin is released into the blood (from the pituitary gland) and into the spinal cord and brain from hypothalamic neurons. The beta-endorphin that is released into the blood cannot enter the brain in large quantities because of the blood-brain barrier. The physiological importance of the beta-endorphin that can be measured in the blood is far from clear: beta-endorphin is a cleavage product of pro-opiomelanocortin (POMC) which is also the precursor hormone for adrenocorticotrophic hormone (ACTH). The behavioural effects of beta-endorphin are exerted by its actions in the brain and spinal cord, and probably the hypothalamic neurons are the major source of beta-endorphin at these sites. In situations where the level of ACTH is increased (e.g. Addison disease), the level of endorphins also increases slightly.
Beta-endorphin has the highest affinity for the μ1-opioid receptor, slightly lower affinity for the μ2- and δ-opioid receptors and low affinity for the κ1-opioid receptors. μ-receptors are the main receptor through which morphine acts. Classically, μ-receptors are presynaptic, and inhibit neurotransmitter release; through this mechanism, they inhibit the release of the inhibitory neurotransmitter GABA, and disinhibit the dopamine pathways, causing more dopamine to be released. By hijacking this process, exogenous opioids cause inappropriate dopamine release, and lead to aberrant synaptic plasticity, which causes addiction. Opioid receptors have many other and more important roles in the brain and periphery however, modulating pain, cardiac, gastric and vascular function as well as possibly panic and satiation, and receptors are often found at postsynaptic locations as well as presynaptically.
[edit] Activity
- 3 more annotations...
-
- Human brain - Wikipedia, the free encyclopedia on 2009-10-14
-
Zombie apocalypse - Wikipedia, the free encyclopedia on 2009-10-14
-
For other uses, see Zombie apocalypse (disambiguation).
[hide]Zombies -
- Zombies, whatever form they take, are unprecedented in the setting of the story; the event that created them is unknown or has never happened before and it is not generally known how to effectively suppress them. The zombies cannot be controlled easily with available technologies.[1]
- Initial contacts with zombies are extremely traumatic, causing shock, panic and disbelief and possibly denial, hampering survivors' ability to deal with hostile encounters.[2]
- The response of authorities to the threat is slower than its rate of growth, giving the zombie plague time to expand beyond containment. This results in the collapse of the given society. Zombies take full control while small groups of the living must fight for their survival.[2]
Genre tropes
There are several common story elements that create a zombie apocalypse:
The stories usually follow a single group of survivors, caught up in the sudden rush of the crisis. The narrative generally progresses from the onset of the zombie plague, then initial attempts to seek the aid of authorities, the failure of those authorities, through to the sudden catastrophic collapse of all large-scale organization and the characters' subsequent attempts to survive on their own. Such stories are often squarely focused on the way their characters react to such an extreme catastrophe, and how their personalities are changed by the stress, often acting on more primal motivations (fear, self-preservation) than they would display in normal life.[2][3]
Generally the zombies in these situations are the slow moving kind first made popular in the 1968 film Night of the Living Dead.[1] Recent films, however, have included zombies that are faster, more agile, and stronger than the traditional zombie.[4] In most cases of "fast" zombies, creators use mindless human beings (as in 28 Weeks Later and Left 4 Dead) instead of re-animated corpses to logically counter the "slow death walk" of Romero's zombies. According to a 2009 Carleton University and University of Ottawa epidemiological analysis, an outbreak of even Living Dead's slow zombies "is likely to lead to the collapse of civilization, unless it is dealt with quickly."[5]
[edit] Subtext
The literary subtext of a zombie apocalypse is usually that civilization is inherently fragile in the face of truly unprecedented threats and that most individuals cannot be relied upon to support the greater good if the personal cost becomes too high.[6] The narrative of a zombie apocalypse carries strong connections to the turbulent social landscape of the United States in the 1960s when the originator of this genre, the film Night of the Living Dead, was first created.[7][8] Many also feel that zombies allow people to deal with their own anxiety about the end of the world.[9] In fact the breakdown of society as a result of zombie infestation has been portrayed in countless zombie-related media since Night of the Living Dead.[10] Kim Paffrenroth notes that "more than any other monster, zombies are fully and literally apocalyptic ... they signal the end of the world as we have known it."[10]
- 8 more annotations...
-
-
Zombie - Wikipedia, the free encyclopedia on 2009-10-14
-
For other uses, see Zombie (disambiguation).
A zombie is a creature that appears in folklore and popular culture typically as a reanimated corpse or a mindless human being. Stories of zombies originated in the Afro-Caribbean spiritual belief system of Vodou, which told of the people being controlled as laborers by a powerful sorcerer. Zombies became a popular device in modern horror fiction, largely because of the success of George A. Romero's 1968 film Night of the Living Dead.[1]
-

- 10 more annotations...
-
-
7chan on 2009-10-14
-

-
what's your zombie loadout, /zom/?
primary weapon:
sidearm:
melee weapon:
explosives:
clothes:
supplies:
ideal sidekick:
-
Highlighter, Sticky notes, Tagging, Groups and Network: integrated suite dramatically boosting research productivity. Learn more »
Join Diigo