Robbie faroby's Profile

These results are interpreted as indicating that addition of fatty acid to liver cells induces various energy-dependent processes, including ATP synthesis, reversed electron transfer and metabolite translocation, all of which contribute to the observed stimulation of O₂ uptake. It is inferred that oxidation of acetyl-CoA to CO₂ is preferentially coupled to ATP synthesis whereas oxidation of fatty acid to acetyl-CoA is obligatorily associated with reversed electron transfer. Thus, ketogenesis is not constrained by the hepatic phosphorylation potential and provides a mechanism for the rapid disposal of fatty acids, independent of the ATP demands of the liver.

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