Not all unusual designs are as intuitive as their designers would like to believe. SOme can be more of a nuisance than a convenience. MIT offer some usability guidelines for websites, which are not detailed but still useful as a quick checklist. If your website’s purpose and content are not immediately understood, you may want to rethink your design. Your content’s structure does not have to be conventional, but it should be logical. Few things are more frustrating to a user than not knowing how to navigate content.
Think of your website like a brand new vehicle. It has some things you are used to: a steering wheel, gears, a seat, etc. When you first sit in it, you immediately recognize certain items, but not others. If the gear shift has been moved from between the seats to behind the steering wheel, you might be confused at first. Not knowing how to shift detracts from the vehicle’s functionality. So, the vehicle’s controls should be clearly labeled and feel natural to use. The relocation of the gear shift is one of the more drastic advancements in the usability of automobiles in recent years and feels quite different from the “layout” of typical car.
While creativity, uniqueness and pushing boundaries always benefit the Web community as a whole, usability is far more important. Your layout and navigation must be intuitive and easy to use to be successful.