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Cindy McInnis's List: Cell signaling

  • Web Quest for Cell Signaling

    Cell communication is imperative for the proper functioning and transmission of signals for our cells. Signals are used by cells in the nervous system, immunogical functions, and endocrine responses just to name a few. The unit here will allow you to explore the exciting world of cell signaling through readings, videos, and interactives.

    To begin this unit read chapter 11 in Campbell Biology 6th edition. Then answer the guided reading questions found on the Campbellbiology web site. Be sure to watch the short simulations for each section.
    1. An overview of cell signaling
    2. Reception
    3. Signal Transduction Pathways

    Once you have completed the work in the book procede through this web quest.

  • Oct 16, 10

    Once at this site click on the cell proliferation signaling pathway.
    1. Cells must go through the process of cell division for an organism to continuing living. How are signals involved in regulating cell division?

    2. What type of receptor is involved in cell division regulation?

    3. How is the signal transduced in the cell?

    3. What is the function of the Cdk molecule that is activated?

    highered.mcgraw-hill.com/...animations.html Cell cycle signaling

  • Oct 16, 10

    Tyrosine Kinase receptor animation

    1. What is different between the tyrosine kinase reception mechanism and those with G-protein receptors? You may have to look in your text to find the answer.

    2. How can problems with this type of receptor cause cancers?

    www.youtube.com/watch

  • Oct 16, 10

    Read through this brief explanation of hormones and receptors.

    arbl.cvmbs.colostate.edu/...hormones.html

  • Oct 16, 10

    Hormones are used for a cascade of signals throughout the body. Make a chart that includes the list of endocrine organs and the hormones that they produce.

    arbl.cvmbs.colostate.edu/...overview.html

  • Oct 16, 10

    Interactive which demonstrates the impact of various signals on tissue. Complete the chart handout that will be given to you in class as you go through this interaction.

    learn.genetics.utah.edu/...signals

  • Oct 17, 10

    Notice the explanation of the different types of second messengers. Follow the links of one hormone for each type and record how their message is carried out in cells.

    arbl.cvmbs.colostate.edu/...surface.html

  • Oct 17, 10

    This video begins with an stimulus to the brain which stimulates the hypothalmus to send a signal to the pituitary gland to relase ACTH (green molecules). The ACTH and the nerve impulses go to the adrenal gland. Epinephrine (blue molecules) is released from the adrenal gland from the nervous system signal.

    The ACTH then attaches to the receptor on the adrenal gland.
    1. What is happening to the receptor?
    2. What complex is being activated?
    3. What do you think is the red molecule in this picture?
    The ultimate signal released in the proces seen in the adrenal cell is cortisol. The cortisol is the molecule seen going further in the bloodstream.
    4. Where does the cortisol travel?

    At time periods 1:45 to 2:20 in the movie the liver cell can be seen receiving the signal from epinephrine that is involved in breaking down glycogen into glucose. Using your book and this movie answer the following questions.

    1. What is the red molecule?
    2. What is the pink molecule?
    3. What is being released?
    4. Where does the glucose that is produced go?

    What does epinephrine do in the other locations that it travels to'
    1. skin
    2. sweat glands
    3. lungs
    4. heart



    www.youtube.com/watch

  • Oct 16, 10

    Watch the following video from the DNA learning center. Answer the questions completely.
    1. What do fibroblast do?
    2. What is the function of growth factors? Use the information in chapter 11 and from this video to explain how the signal is transferred through the cytoplasm.
    3. What is the type of protein that is being activated (the white protein)? What is this step in cell signaling called?
    4. The growth factors that are produced are released by the cell for what purpose?

    www.youtube.com/watch

  • Oct 16, 10

    1. How is leptin involved in cell signaling?

    2. What happens when leptin is not produced?

    3. If you were to design a drug for this problem what would you focus on- the genetics or signal issue or both? Explain your idea in detail.

    www.pbs.org/...obesity.html

  • Oct 16, 10

    Not only does signaling happen in animals and plant, but also bacteria. Watch this fascinating video about the signaling of bacteria.

    1. Explain the new antibiotic possibilities discussed by Dr. Bassler due to cell signaling.

    2. Explain quorum sensing and how it relates to cell signaling.

    www.ted.com/..._how_bacteria_communicate.html

  • Oct 16, 10

    Read over this web site on endocrine disruptors.

    whyfiles.org/...index.html

  • Research a Cell Communication Malfunction Disease

    Use the internet to research a disease that is based on the malfunction of cell communication.
    Find out the following in your research of your disease:
    1. What is the cause of the disease (relate to cell communication)?

    2. Explain in detail the cell communication system that is suppose to occur.

    3. Identify the specific type of commucation problem that caused the disease.

    4. What are the symptoms of the disease and how does it relate to what is happening on a cellular level?

    5. Identify the current treatments and whether or not they address the communciaton issue.

    Prepare a presentation using an online source such as Prezi or Voicethread and post it to the class moodle site.
    The rubric will be provided in class.

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