Neuropathic Chronic Pain

Web Address: http://www.diigo.com/list/dwalker3rd/pain

You are here: Diigo Home > David Walker > David Walker's lists

David Walker

Items:5 | Visits:3

Category:Health & Wellness | Tags:pain, chronic, neuropathic

Created:on 2008-05-09 | Updated:on 2008-05-09

Items related to chronic neuropathic pain with possible kidney stone links.

Expand All

1 - 5 of 5

0Expand
Amitriptyline - Wikipedia, the free encyclopedia

This is what I'm taking. 25mg 1/day 1/hr before bedtime

Tags: amitriptyline, antidepressant, pain on 2008-05-09 -All Annotations (0) -About

more fromen.wikipedia.org
5Expand
Antidepressants and chronic pain -- McQuay and Moore 314 (7083): 763 -- BMJ

Tags: antidepressants, tricyclic, neuropathic, pain on 2008-05-09 -All Annotations (0) -About

more frombmj.bmjjournals.com
- The speed of onset of effectis much faster
  (one to seven days) than that reported in depression,and the analgesic effect is distinct from any
  effect on mood.⁷
- Theprimary role is when pain
  relief with conventional analgesics(from aspirin or paracetamol through to morphine) is
  inadequateor when pain relief is combined with intolerable or unmanageableadverse effects
- A secondary role of antidepressants in treating chronic painis their use in addition to
  conventional analgesics.
- The
  common first choice is amitriptyline, with a startingdose of 25 mg (10 mg in frail patients) to
  be taken as a singlenight time dose one hour before lights out. We advise patientsto increase the
  dose by 25 mg at weekly intervals until theyeither achieve pain relief or adverse effects become
  problematic.The maximum dose is 150 mg. Patients are warned to expect adry mouth and
  drowsiness, which is why they should take thedrug at night. If they are still drowsy first thing
  in the morningthey should take the drug earlier in the evening.
- One obvious question is what happens in the long term. Mostevidence of efficacy comes
  from short term trials (lasting weeksto months), and, although many patients continue to achieve
  painrelief with antidepressants for months to years, this is nottrue for everybody. Another
  puzzle is how antidepressants workas analgesics. The standard (but not compelling) explanation
  isthat they act on descending tracts from the brain via noradrenalineand serotonin systems to
  modulate signalling of pain in thespinal cord. This sounds, and is, an unsatisfactory explanation.
  Butin the meantime it is clear that antidepressants have an importantrole to play in relieving
  chronic pain.
2Expand
Tricyclic antidepressant - Wikipedia, the free encyclopedia

Tags: tricyclic, antidepressant, pain on 2008-05-09 -All Annotations (0) -About

more fromen.wikipedia.org
- The exact mechanism of action is not well understood, however it is generally thought that tricyclic antidepressants work by inhibiting the re-uptake of the neurotransmitters norepinephrine and serotonin by neurons. Tricyclics may also possess an affinity for muscarinic and histamine H1 receptors to varying degrees. Although the pharmacologic effect occurs immediately, often the patient's symptoms do not respond for 2 to 4 weeks.^[4] Although norepinephrine and dopamine are generally considered stimulatory neurotransmitters, tricyclic antidepressants also increase the effects H1 histamine, and thus most have sedative effects.^[5]
- The chemical action of re-uptake inhibitors in general was unknown for a long time. In August 2007, two research groups independently reported that the tricyclic molecule docks to the transporter protein in a cavity adjacent to where the neurotransmitter substrate binds, locking the substrate in place and thereby obstructing re-uptake transport.^[6]
1Expand
UK National Kidney Federation - Kidney Disease - Pain Control

Tags: kidney, pain on 2008-05-09 -All Annotations (0) -About

more fromwww.kidney.org.uk
- Management of persistent pain and psychological effects of pain
  
  Most people with kidney pain get better with treatment (eg treatment of infection or removal of a stone). However, some people do get long term (chronic) pain. Pain that will not go away is one of the worst medical problems anyone can have. There are a number of ways that someone can try to deal with pain. One is to have a satisfactory diagnosis and plan of treatment from a specialist. However, even with the help of drugs, a specialist cannot always get rid of pain. Therefore finding a strategy that helps you cope with the pain may be needed. This may require the help of a hospital pain specialist or a psychologist. Some people get relief from alternative therapies such as acupuncture. Click here for further advice on coping with long term pain.
4Expand
UK National Kidney Federation - Kidney Disease - Pain Control

12 Steps Towards Pain Control

Tags: pain on 2008-05-09 -All Annotations (0) -About

more fromwww.kidney.org.uk
- Accept the fact of having long term (chronic) pain
  
  Set specific goals for work, recreation or hobbies and social activities toward which you can work
  
  Let yourself get angry at your pain if it seems to be getting the best of you
  
  Take your painkilling medications on a strict time schedule, and then taper them off
  
  Get in the best physical shape possible, then keep fit
  
  Learn how to relax, and practice relaxation regularly
  
  Keep yourself busy
  
  Pace your activities
  
  Persuade your family and friends to support only healthy behaviour, not your pain
  
  Be open and reasonable with your doctor<
  
  Practice effective empathy with others having pain problems
  
  Remain hopeful
- Long-term use of some powerful painkillers leads to tolerance (they do not get rid of the pain), physical dependence and addiction, and also has unpleasant side effects. Narcotics (powerful painkillers like morphine) taken “as needed” in chronic pain states tend to have the paradoxical effect of maintaining pain at an abnormally high level, as well as keeping you more mentally dull and irritable than you want to be. Most people with chronic pain function better when they withdraw in a gradual and systematic way from narcotics.
- because of its beneficial effect on raising your pain tolerance while helping to discharge the tensions which develop each day from having to cope with pain
- ou will also need to reduce the intake of stimulants such as caffeine

1 - 5 of 5

List 20 50 100

List Comments (0)

Neuropathic Chronic Pain

Amitriptyline - Wikipedia, the free encyclopedia

Antidepressants and chronic pain -- McQuay and Moore 314 (7083): 763 -- BMJ

Tricyclic antidepressant - Wikipedia, the free encyclopedia

UK National Kidney Federation - Kidney Disease - Pain Control

Management of persistent pain and psychological effects of pain

UK National Kidney Federation - Kidney Disease - Pain Control

David Walker's Public Lists (4)

Diigo - Highlight and Share the Web!