Making memories last - The Diigo Meta page

• 10 Jan 13
  

  Caroline Leaf
  • CPEB's tendency to oligomerize is not merely incidental, but is indeed essential to its ability to stabilize longer-term memory.
• 05 Feb 12
  

  R T

  prion

• 02 Feb 12
  

  Michael Bolanos
• 31 Jan 12
  

  Sarah Felicelli
• 29 Jan 12
  

  Gareth Stack

  oligomers

  memory ltp

• 28 Jan 12
  

  Matt Perez

  a synapse-maintenance protein known as CPEB (Cytoplasmic Polyadenylation Element Binding protein) has an unexpected property.
  A portion of the structure is self-complementary and -- much like empty egg cartons -- can easily stack up with other copies of itself. CPEB thus exists in neurons partly in the form of oligomers, which increase in number when neuronal synapses strengthen. These oligomers have a hardy resistance to ordinary solvents, and within neurons may be much more stable than single-copy "monomers" of CPEB. They also seem to actively sustain their population by serving as templates for the formation of new oligomers from free monomers in the vicinity.

  neuroscience memory oligomers

  • They also seem to actively sustain their population by serving as templates for the formation of new oligomers from free monomers in the vicinity.

     

Would you like to comment?

Join Diigo for a free account, or sign in if you are already a member.