This link has been bookmarked by 9 people . It was first bookmarked on 28 Jan 2012, by Matt Perez.
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10 Jan 13
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CPEB's tendency to oligomerize is not merely incidental, but is indeed essential to its ability to stabilize longer-term memory.
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05 Feb 12
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02 Feb 12
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31 Jan 12
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29 Jan 12
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28 Jan 12
Matt Pereza synapse-maintenance protein known as CPEB (Cytoplasmic Polyadenylation Element Binding protein) has an unexpected property.
A portion of the structure is self-complementary and -- much like empty egg cartons -- can easily stack up with other copies of itself. CPEB thus exists in neurons partly in the form of oligomers, which increase in number when neuronal synapses strengthen. These oligomers have a hardy resistance to ordinary solvents, and within neurons may be much more stable than single-copy "monomers" of CPEB. They also seem to actively sustain their population by serving as templates for the formation of new oligomers from free monomers in the vicinity.-
They also seem to actively sustain their population by serving as templates for the formation of new oligomers from free monomers in the vicinity.
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