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nightsurfer on 2009-09-05Geographic variation of prostate cancer mortality rates in the United States: Implications for prostate cancer risk related to vitamin D.
Int J Cancer. 2004 Sep 1;111(3):470-1; author reply 472. No abstract available.
The implications of our results and those of Tuohimaa et al. include the following. Vitamin D supplementation should be undertaken in wintertime, a period when it is impossible to produce vitamin D by solar UVB exposure in northeastern states. Given these new results, the optimal vitamin D intake and production and serum 25(OH)-vitamin D3 levels for prostate cancer appear to be lower than for other cancers. However, when developing guidelines for vitamin D fortification, many factors should be included in the analysis, including all of the potential health benefits and possible risks of vitamin D, as well as age, sex, residence, child-bearing status, etc. Also, the suggestion that daily vitamin D3 supplement doses of 100 g (4,000 IU)/day are safe should be reexamined. Finally, in terms of preventing prostate cancer, more attention should be given to diet, which has the greatest environmental impact on risk of prostate cancer, with animal products being important risk factors and vegetable products, especially onions and other allium family members, being important risk-reduction factors.