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VNP40541 is an anticancer agent in late stage preclinical development. It exhibited potent anticancer activities in preclinical studies and is activated under hypoxic (low oxygen) conditions.
Q: What is VNP40541 and how does it work? >
A: VNP40541 is a hypoxia-selective anticancer agent that is being evaluated in preclinical studies. Hypoxic, or low-oxygen, tumor cells, representing a fraction of the whole tumor, are resistant to cancer treatment modalities including radiation and chemotherapy. Complete regression of solid tumors requires strategies that eradicate tumor cells within the hypoxic regions. VNP40541 converts to a cytotoxic compound only under hypoxic conditions. VNP40541 remains relatively inactive under oxic conditions. Upon activation in hypoxic conditions, VNP40541 liberates the DNA chloroethylating species 90CE, which is the same active metabolite released by Cloretazine® (VNP40101M). 90CE produces interstrand DNA cross-links that are difficult to repair and are toxic to cells. VNP40541is designed to be selective for tumor cells. Since almost all solid tumors contain hypoxic regions, it is expected that VNP40541 will work well in combination with other anticancer agents. >
Q: What is the status of VNP40541 product development? >
A: Human clinical trials are expected to commence in 2007. >
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