PLoS ONE: Evolving Synaptic Plasticity with an Evolutionary Cellular Developme... - The Diigo Meta page

• 15 Nov 08
  

  the drawback of all the encodings presented above is that they are either not based on biological processes, or lack the multiple interactions among different developmental phenomena that result in the emergence of biologically plausible models. Thus, des

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  • Synaptic plasticity has long been regarded as a potential mechanism for memory formation and learning. The most famous synaptic plasticity principle is known as Hebbian learning [23], where modifications in synaptic transmission efficacy are driven by correlations in the firing activity of presynaptic and postsynaptic neurons.

     

    Over the last 30 years, a large body of experimental results on synaptic plasticity has been accumulated. The long- lasting enhancement of synaptic transmission, Long Term Potentiation (LTP) first reported in 1973 [24], along with its counterpart Long-Term Depression (LTD), has been the focus of an enormous amount of investigation. Several experiments on various neuronal systems have found that synaptic plasticity may also depend on accurate spike timing; Spike Timing Dependent Plasticity (STDP) [25]–[29].

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