Rudy Garns's personal annotations on this page
Tsien, based at Princeton University in New Jersey at the time, named his creation Doogie after the teenage genius in the television programme Doogie Howser, MD. The work was one of the earliest examples of neuroscientists using genetic engineering to generate cognitively enhanced animals in a bid to understand memory and learning.
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neuroscientists using genetic engineering to generate cognitively enhanced animals in a bid to understand memory and learning.
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Much of the work involves making an adult brain behave more like a younger, more flexible version of itself by increasing the organ's plasticity.
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Tsien created Doogie by overexpressing a subunit of the NMDA receptor called NR2B. This kept the receptors open for longer, strengthening the synaptic link and making it easier for disparate events to be linked together.
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Rudy GarnsTsien, based at Princeton University in New Jersey at the time, named his creation Doogie after the teenage genius in the television programme Doogie Howser, MD. The work was one of the earliest examples of neuroscientists using genetic engineering to generate cognitively enhanced animals in a bid to understand memory and learning.
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neuroscientists using genetic engineering to generate cognitively enhanced animals in a bid to understand memory and learning.
-
Much of the work involves making an adult brain behave more like a younger, more flexible version of itself by increasing the organ's plasticity.
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