actually EQUETRO (no "S")
This link has been bookmarked by 1 people . It was first bookmarked on 22 Apr 2007, by Dr Green.
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22 Apr 07
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Olanzapine-treated patients demonstrated a nearly 6-point statistically significant greater decrease in their total YMRS score than placebo-treated patients. Further, the olanzapine effect was observable as early as 1 week after initiation of treatment
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comparing valproate (500-2500 mg/day adjusted to a plasma range of 50-125 mcg/mL) with olanzapine (5-20 mg/day) in the treatment of acute mania,[7] response rates (≥ 50% decrease in YMRS score) for olanzapine and valproate were 54% and 42%
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remission
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response
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quetiapine (titrated to 800 mg/day) combined with lithium or valproate for 21 days in patients with acute mania demonstrated a significant and clinically meaningful advantage for the quetiapine plus mood stabilizer combination
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2-week study comparing monotherapy with lithium, quetiapine, or placebo in the treatment of acute mania,[16] the efficacy of quetiapine was superior to placebo and comparable to lithium.
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in the treatment of acute mania demonstrated significant separation from placebo on YMRS scores for haloperidol as early as day 4, and for quetiapine starting at day 21
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econd study, which pooled results from 2 separate monotherapy trials with quetiapine (up to 800 mg/day), demonstrated significant improvement as early as day 4
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Combination therapy did not significantly reduce syndromic relapse rates into either mania or depression
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continued in a maintenance treatment phase on either lithium (plasma levels of 0.6-1.2 mmol/L) or valproate (plasma levels of 50-125 mcg/mL). This was followed by a double-blind trial in which patients received either olanzapine (5-20 mg/day combination therapy, n = 51) or placebo (n = 48, monotherapy)
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However, other studies have shown a much more rapid antimanic effect for valproate than the median of 62 days reported here
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] This would suggest there is comparable efficacy between the 2 agents in the maintenance of bipolar disorder but a more rapid antimanic effect for olanzapine,
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Median time to remission of mania was 14 days for olanzapine and 62 days for valproate. However, over the 47-week follow-up,
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long-term efficacy of olanzapine in bipolar disorder has also been investigated in a 47-week trial that compared olanzapine (5-20 mg/day) with valproate (500-2500 mg/day) for acute mania and in a maintenance follow-up study.
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also exhibited a significant reduction in the HAMD-21 total scores to a greater extent than the mood stabilizer plus placebo group
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esponse rates, defined by ≥ 50% improvement on the YMRS, were also greater with the antipsychotic-mood stabilizer combination (68% vs 45%)
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maintained on their mood stabilizer and randomized to either olanzapine (5-20 mg/day) or placebo augmentation
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Furthermore, remission rates, problematically defined as YMRS ≤ 12 in this study, were 47% for olanzapine-treated patients and 34% for valproate-treated
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A second double-blind, randomized, controlled trial comparing valproate (500-2500 mg/day) with olanzapine (5-20 mg/day) showed comparable results during the 21-day treatment period for the 2 agents,
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Add Sticky NoteEquestro
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Add Sticky NoteQuetiapine
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NOW FDA-APPROVED FOR BIPOLAR MAINTENANCE, at *least* as adjunc to Li/VPA (but also monotherapy??)
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Public Stiky Notes
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