Direct and indirect cannabinoid agonists reduce L-dopa-induced-dyskinesias via... - The Diigo Meta page

• 11 Oct 09
  

  Sigalon - The Swedish Frog

  "Interestingly, subchronic co-administration of URB597 and capsazepine (10mg/kg), a selective TRPV1 antagonist, significantly decreased all L-dopa-induced AIMs subtypes, whereas capsazepine had no effect when administered alone. Our data suggest that CB1 and TRPV1 receptors play opposite roles in levodopa-induced dyskinesias."

  pd

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