This link has been bookmarked by 1 people . It was first bookmarked on 18 Nov 2007, by Dr Green.
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18 Nov 07
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Electrocardiographic changes such as QTc prolongation have been reported in citalopram (Celexa) ingestions in particular
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Neuroleptic malignant syndrome, associated with dopamine antagonists, has a slower onset of symptoms than SS and is associated with bradykinesia and "lead-pipe" muscular rigidity, rather than hyperkinesias and tremors. Anticholinergic toxicity involves dry erythematous skin, enlarged pupils (mydriasis), decreased bowel sounds, and normal reflexes in contrast to serotonin toxicity, which includes diaphoresis, increased bowel sounds, diarrhea, and hyperreflexia.
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detection of dextromethorphan by cross-reactivity
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Treatment of serotonin syndrome is primarily supportive
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Treat rhabdomyolysis with aggressive hydration, and alkalinize urine with sodium bicarbonate for renal protection.
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benzodiazepines for agitation/restlessness
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hyperthermia with cooling blankets, fans, ice packs, and intravenous fluids
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Administer activated charcoal if a potentially lethal amount has been ingested and if presentation is within 1-2 hours.
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Treat neuromuscular abnormalities with benzodiazepines.
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hyperthermia, depressed mental status, and vital sign abnormalities
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cyproheptadine has anticholinergic properties and theoretically can worsen hyperthermia.
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nitroprusside and esmolol.
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rhabdomyolysis
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Poison Control Center at (800) 222-1222
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