Diagramming Disease Networks with Chemical and Biological Tools
We are diagramming the interconnected signaling networks underlying cancer and neurodegenerative diseases using chemical and biological tools. Our approach is to design high-throughput screens in mammalian cells that allow us to test tens of thousands of small organic molecules and small interfering RNAs for their ability to affect cellular phenotypes associated with oncogenic signaling or neurodegeneration. These screens reveal reagents that are used to identify specific proteins and genes that act as the critical regulators of cellular disease pathologies. We define the molecular function of these critical regulators using protein biochemistry, molecular cell biology and chemical synthesis.
Potential research projects include:
identifying the protein targets and signaling pathways affected by novel compounds we have discovered in screens related to cancer and neurodegeneration
creating and executing high-throughput screens related to oncogenic signaling and neurodegeneration to identify novel compounds and genes of interest
defining protein ligation events (ubiquitylation, sumoylation, etc) associated with specific disease proteins
creating novel photoaffinity reagents, fluorescent sensors and chemical libraries
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