This link has been bookmarked by 2 people . It was first bookmarked on 28 Jun 2008, by Mud Doccy.
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23 Mar 15
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The role of dopamine is intriguing in view of its role in decision-making—compulsive individuals are habitually indecisive—and because the basal ganglia, which are heavily endowed with dopaminergic fibres, are an important substrate for OCD symptoms.
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The study suggests that chronic stimulation of these D1 expressing neurons induces complex compulsive behavior that resembles symptoms of OCD in humans. Although these mice were resistant to behavioral inhibition by a D1 receptor antagonist and supersensitive to the D2 receptor antagonist sulpiride, Campbell and colleagues6 suggested that chronic stimulation of cortical and limbic D1 expressing neurons may cause obsessive-compulsive behaviors.
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In summary, these data animal models for OCD suggest a role for dopamine, in particular of the D1 and D2 receptors, and serotonin, most likely the 5-HT2C receptors, in the mechanism underlying compulsive behavior in animals.
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Methylphenidate and amphetamine have been reported to exacerbate or induce as well as to improve OCD symptoms.
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28 Jun 08
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In an open trial, Metin and colleagues82 evaluated the efficacy of amisulpiride 325 mg/day, a selective dopamine D2/3 receptor antagonist, to augment the effect of SSRI treatment in 20 patients with treatment-resistant OCD and observed a significant improvement in 95% of the patients.
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Denys and colleagues87 found that the combination of quetiapine and fluvoxamine may cause a synergistic dopamine increase in the prefrontal cortex and thalamus.
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