Neurophilosophy : Erasing memories - The Diigo Meta page

• 25 Oct 08
  

  neuro brain memory PTSD

  • CaMKII is found only in the brain, and it constitutes more than 1% of the proteins in that organ. It is highly enriched in the postsynaptic density (PSD), a dense network of more than 1,000 proteins, organized into 12 massive and precisely assembled multi-protein signalling pathways, located immediately underneath the membrane of neurons which use glutamate as a neurotransmitter.
  • The impairments could have been due to the disruption any of the three stages of memory: acquisition, retention or retrieval. The researchers therefore devised an experiment to distinguish between each of these processes. Another group of experimental and control mice were taught the same memory tasks and the former was treated with the αCaMKII inhibitor 15 minutes before the recall tests.
  • Last year, another group of researchers reported that memories could be erased by inhibiting another enzyme called protein kinase M zeta. This inhibitor only worked if applied for at least 2 hours after learning, and it had a general effect on all the memories encoded at the same time.

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