Even without Portable Thunderbird, it is fairly easy to run Thunderbird from a portable USB drive. The key is to launch Thunderbird using the -profile "path" command line argument, where "path" is the location of the profile you want to use. The path should be in quote marks if it includes any spaces. For example, on Windows if the Thunderbird program is installed on drive F in a folder called "Mozilla Thunderbird" and your profile is located in a folder called "My TB profile", you would use this syntax:
Portable Thunderbird OSX repackages an official build of Thunderbird for OSX, using a Platypus script. Its a unrelated effort, not developed by the same person who developed Portable Thunderbird.
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