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14 Nov 08
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17 Sep 08
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The biphasic or nonmonotonic dose-response curves observed in this and many other studies of BPA follow an inverted U shape, which is a common finding for endocrine-active chemicals and drugs, for which high doses inhibit (down-regulate) the low-dose response system while initiating a wide array of other adverse effects via different response mechanisms.10
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A fundamental problem is that the current ADI for BPA is based on experiments conducted in the early 1980s using outdated methods (only very high doses were tested) and insensitive assays. More recent findings from independent scientists were rejected by the FDA, apparently because those investigators did not follow the outdated testing guidelines for environmental chemicals, whereas studies using the outdated, insensitive assays (predominantly involving studies funded by the chemical industry) are given more weight in arriving at the conclusion that BPA is not harmful at current exposure levels.
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causal role for BPA in these trends is plausible because BPA can alter the programming of genes during critical periods in cell differentiation during fetal and neonatal development. This process, referred to as "epigenetic programming," can result in the expression of metabolic disease and cancers during later life.
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worldwide BPA production has now reached approximately 7 billion pounds per year
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16 Sep 08
Tommy MilesJAMA, the Journal of the American Medical Association, is a highly cited weekly medical journal that publishes peer-reviewed original medical research findings and editorial opinion
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