This link has been bookmarked by 6 people . It was first bookmarked on 24 Sep 2006, by Milo Han.
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03 Sep 13
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The passenger strand is degraded, and the guide strand is incorporated into the RNA-induced silencing complex (RISC)
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induces cleavage by Argonaute, the catalytic component of the RISC complex.
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25 Aug 11
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RNA interference (RNAi) is a system within living cells that takes part in controlling which genes are active and how active they are.
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The RNAi pathway
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is initiated by the enzyme Dicer, which cleaves long double-stranded RNA (dsRNA) molecules into short fragments of ~20 nucleotide
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The most well-studied outcome is post-transcriptional gene silencing, which occurs when the guide strand base pairs with a complementary sequence of a messenger RNA molecule and induces cleavage by Argonaute, the catalytic component of the RISC complex. This process is known to spread systemically throughout the organism despite initially limited molar concentrations of siRNA.
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08 Feb 10
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Lentiviral Delivery of designed shRNA's and the mechanism of RNA interference in mammalian cells.
RNA interference (RNAi) is a system within living cells that helps to control which genes are
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05 Sep 07
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24 Sep 06
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produce double-stranded fragments of 21-23 base pairs
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